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I. P. Smirnova ¹, S. P. Syatkin ², T. A. Lobaeva ¹, A. S. Skorik ¹, S. M. Chibisov ³, M. L. Blagonravov ³, G. I. Myandina ⁴, V. I. Kuznetsov ⁴

Affiliations
1 1T. T. Berezov Department of Biochemistry of PFUR. Moscow, RU
2 Peoples’ Friendship University of Russia (PFUR), Miklukho-Maklaya str., 8, Moscow, RU
3 Department of Pathological Physiology of PFUR, Moscow, RU
4 Department of Biology and General Genetics of PFUR, Moscow, RU

Abstract

We studied the immunomodulatory activity of L-lysine-α-oxidase (LO) from Trichoderma harzianum Rifai F- 180 to model endogenous colony-forming cells surface of the spleen of the mice of line F/SVA С157В1. LO shows immunomodulatory activity on models in vivo and in vitro.

Keywords

L-lysine-α-Oxidase, x-Ray, Immunomodulatory Activity.

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N. G. Kulchenko ¹, S. M. Chibisov ¹, I. Z. Eremina ¹, M. A. Vekilyan ², S. P. Syatkin ¹, A. S. Skorik ¹, G. I. Myandina ¹, N. A. Shevkun ¹, E. V. Neborak ¹

Affiliations
1 Federal State Budgetary Institution of Higher Professional Education “People’s Friendship University of Russia”, Mikloukho-Macklay Street, 6, Moscow, 117198, RU
2 Department of Urology of Non-Governmental Healthcare Institution of Regional Clinical Hospital at the Station Volgograd-1, JSC "Russian Railways", Avtotransportnaya Street, 75, Volgograd, 400131, RU

Abstract

Secondary pyelonephritis occurs in 48.3% - 89.3% of cases and complicates the states of the disease. The effectiveness of therapy and prognosis of the disease depends on chosen methods of antibiotic prophylaxis of pyoinflammatory kidney diseases. The purpose of the research: To improve the results of patients' treatment with complicated calculous pyelonephritis. Materials and methods: We have examined 179 people. This was a retrospective pharmacoepidemiological analysis of medical documents of patients, treated in 2009 and in 2013 in a hospital of Volgograd. The number of women, taking part in the research was 99 (55.4%) and men - 80 (44%). All patients underwent a standard clinical examination, with the mandatory bacteriological urinalysis, renal ultrasound. Results: Among patients with chronic calculous pyelonephritis, the most common infectious agents are the following: E.coli - 72,4%, Staph. epidermidis - 20,8%, P. aeruginosa - 26,8%. The greatest sensitivity to infectious agents possess the next preparations: carbopenems (meronems) - 92%, amoxicillin + clavulanic acid - 86.4%, cefotaxime - 89.4%. The greatest resistance of E.Coli is to ciprofloxacin and ampicillin. Conclusions: The regular review of recommendations for antimicrobial therapy of urinary tract infections is necessary, due to the constant changes in the level of uropathogens resistance.

Keywords

Urolithiasis, Calculous Pyelonephritis, Antibiotic Sensitivity.

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N. G. Kulchenko ¹, A. A. Kostin ², S. M. Chibisov ¹, I. Z. Eremina ¹, A. O. Tolkachev ², S. P. Syatkin ¹, A. S. Skorik ¹, G. I. Myandina ¹, M. L. Blagonravov ¹, V. I. Kuznetsov ¹

Affiliations
1 Federal State Budgetary Institution of Higher Professional Education, “People’s Friendship University of Russia”, Mikloukho-Macklay Street, 6, Moscow, 117198, RU
2 Federal State Budgetary Institution “National Medical Research Radiological Centre” of the Ministry of Health of the Russian Federation, RU

Abstract

Among the main methods of prostate cancer diagnosing, such as finger rectal examination, prostate-specific antigen test, ultrasound examination of prostate, none of them possesses enough specificity and sensitivity. In our research, we used special statistic and mathematic processing (multifactor analysis and binary logic regression) of main prostate cancer symptoms, which allows to suspect prostate cancer with 97% accuracy and also to reduce the frequency of unnecessary biopsies of prostate.

Keywords

Prostate Cancer, Benign Prostatic Hyperplasia, Early Diagnosis.

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O. M. Yuldashova ¹, S. M. Chibisov ², R. O. Karybekova ³, M. V. Abramova ², S. P. Syatkin ², E. V. Neborak ², I. P. Smirnova ², G. I. Myandina ², M. L. Blagonravov ², V. I. Kuznetsov ²

Affiliations
1 Osh State University, RU
2 RUDN University, RU
3 Osh Interregional Children's Hospital, RU

Abstract

The size of chest circumference of 1578 Kyrgyz male born at different altitudes were estimated during the observation period from 2003 to 2011. The study found the following correlation: the higher altitude at which the neonates were born, the lower was their chest circumference.

Keywords

Chest Circumference, Newborn, Altitude.

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S. M. Chibisov ¹, M. V. Abramova ¹, M. L. Blagonravov ¹, J. V. Voropaeva ², S. A. Meladze ², S. P. Syatkin ¹, E. V. Neborak ¹, I. P. Smirnova ¹, G. I. Myandina ¹, V. I. Kuznetsov ¹

Affiliations
1 RUDN University, RU
2 Research Clinical Pediatric Pirogov Institute GBOU VPO of the Ministry of Health of Russia, Moscow, RU

Abstract

Currently there is no consensus about the etiology and pathogenesis of the conditions, manifested by a persistent increase in the thymus gland. A retrospective long-controlled study conducted on the basis of computer monitoring clinical examination of children discrete ages to test hypothesis about the sensitivity of the thymus gland during embryogenesis to heliogeomagnetic fluctuations (magnetic storms). The results showed that children with a persistent increase in the thymus and in healthy children during ontogeny (embryogenesis) geomagnetic conditions significantly different. It is assumed that the low level of geomagnetic activity during the final formation of all areas of the thymus (emigration of T-lymphocytes, check their peripheral lymphoid organs and in the period of active growth of the parenchyma of the thymus) may be a risk factor for persistent hyperplasia of thymus. The data obtained do not contradict the idea that developing structures required a certain optimum level cosmophysical impact.

Keywords

Children, the Thymus Gland, Thymus, Timomegalia, Solar Activity, Heliogeomagnetic Activity, Heliogeomagnetic Indexes, Critical Periods of Embryogenesis, Fetal Development, Prenatal Development, Gestational Periods.

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I. V. Rakovskaya ¹, I. P. Smirnova ², S. P. Syatkin ², G. I. Myandina ², S. M. Chibisov ², M. L. Blagonravov ², A. S. Skorik ²

Affiliations
1 Federal State Budgetary Institution “Research Institute of Epidemiology and Microbiology Named after Honorable academician N. F. Gamaleya”, 16 Gamalei Str, Moscow, RU
2 Medical Department of Medical Institute of Peoples’ Friendship University of Russia, 6 Miklukho-Maklaya Str., Moscow, RU

Abstract

Concentrate of the culture liquid of Trichoderma harzianum Rifai F-180-producer of the enzyme L-lysine-α- oxidase with activity in the culture fluid 0,54-0,56 U/ml was obtained by culturing in the fermenter. For the first time we studied the influence of obtained concentrate on the growth of Mycoplasma: 2 species of the family Мycoplasmataceae: Mycoplasma hominis (Mh) and Mycoplasma fermentans (Mf) and one species representative of the family Aholeplasmataceae: Aholeplasma laidlawii (Al). It is shown that the cultural liquid of Trichoderma producer of the enzyme L-lysine-α-oxidase inhibits the growth of Mycoplasma hominis after the preliminary contact. The degree of growth inhibition depends on the sowing dose of Mycoplasma and concentration of the culture fluid of Trichoderma.

Keywords

L-lysine-α-Oxidase, Concentrate of Trichoderma, Mycoplasma.

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V. F. Larichev ¹, I. P. Smirnova ², S. P. Syatkin ², G. I. Myandina ², S. M. Chibisov ², Е. А. Ryskina ²

Affiliations
1 Federal State Budgetary Institution “Research Institute of Epidemiology and Microbiology Named after Honorable Academician N. F. Gamaleya”, 16 Gamalei Str, Moscow, RU
2 Medical Department of Medical Institute of Peoples’ Friendship University of Russia, 3 Ordzhonikidze Str., Moscow, RU

Abstract

For the first time we studied the effect of the anticancer drug L-lysine-α-oxidase, obtained from culture liquid of Trichoderma harzianum Rifai F-180.

In vitro experiments we established the high activity of L-lysine-α-oxidase in a model of tick-borne encephalitis and the lack of activity against viruses Sindbis, West Nile, Tahyna and Dhori.

Keywords

L-lysine-α-Oxidase, Arboviruses, Tick-Borne Encephalitis, Cytopathic Effect, Antiviral Activity.

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M. V. Dementyev ¹, S. M. Chibisov ², M. V. Abramova ², S. D. Beeharry ², M. L. Blagonravov ², S. P. Syatkin ², E. V. Neborak ², I. P. Smirnova ², G. I. Myandina ², V. I. Kuznetsov ²

Affiliations
1 South Ural State Hospital, Chelyabinsk, RU
2 RUDN University, RU

Abstract

To prevent disease it is not enough to eliminate only modifiable factors but it is also necessary to identify patients at a preclinical stage, when physiological parameters are still within normal limits, but there is an excess stress on the regulation systems. In this study, we aim to examine the parameters of the cardiovascular system(CVS) from their physiological limits to diagnose desynchronization at an early stage.

Keywords

Desynchronosis, Shift Work, Desynchronization, Driver, Prophylaxis.

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